Title: Here Is a Human Being: At the Dawn of Personal Genomics
Author: Misha Angrist
Year: 2010 (Paperback 2011)
Acquired: From the publisher for review consideration
Review: In 2007, Misha Angrist agreed to make his innermost secrets public for the world to see. As participant number four in the Personal Genome Project, Angrist agreed to let his entire genome be sequenced and then made available to researchers looking for samples to test in genetics research. While most medical research tries to work with anonymous samples, the Personal Genome Project required participants to be public because research into our genes works best when researchers can compare whats in our DNA to how that blueprint is expressed. In a very real way, Angrist and the other participants agreed to bare it all in the name of science.
In Here Is a Human Being, Angrist chronicles his experience being a part of this groundbreaking project. As a participant and observer, Angrist comes at the entire world of personal genomics with a unique and engaging perspective. And if there’s one thing the book makes absolutely clear, it’s that our genome can tell an awful lot about us while simultaneously telling us nothing useful at all.
Here Is a Human Being does what many of my favorite science books are able to do — take the reader inside science to see how the whole process of innovation and discovery works. The path to sequence the human genome, like the path towards many lofty scientific goals, has not been straightforward or without setbacks, and Here Is a Human Being does a good job getting behind the big news to show the people and their process.
The book also does an admirable job explaining the implications of personal genomics for the average person: What would knowing your genome mean? How useful would it be? What risks does sharing your genome publicly come with? I liked that Angrist was open with his own misgivings and concerns about making his genome public, as well as how he came to the decision to participate.
Here Is a Human Being doesn’t have the sort of victorious ending that many books about medical discoveries have. There’s no big reveal when Angrist finally sees his genome, no major mutation that somehow changes his life or incredible scientific breakthrough that moves the process of genome sequencing forward.
Instead, the book is a sort of chronicle of the moment, a look at how far the process of person genomics has come and an acknowledgement of how much there is that we still don’t know. The book is a personal and engaging look at what the future of genome sequencing could be and piqued my interest in what is to come.
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